Activity of Pt(II) and Ru(III) Triazolopyrimidine Complexes Against Parasites of the Genus Leishmania, Trypanosomas and Phytomonas | Zendy

Juan M. Salas | Zendy; M. Quirós | Zendy; Mohammad Abul Haj | Zendy; Rosa Magán | Zendy; Clotilde Marı́n | Zendy; Manuel Sáchez-Moreno | Zendy; R. Faure | Zendy

Open Access

Activity of Pt(II) and Ru(III) Triazolopyrimidine Complexes Against Parasites of the Genus Leishmania, Trypanosomas and Phytomonas

Author(s) -

Juan M. Salas,

M. Quirós,

Mohammad Abul Haj,

Rosa Magán,

Clotilde Marı́n,

Manuel Sáchez-Moreno,

R. Faure

Publication year - 2001

Publication title -

metal-based drugs

Language(s) - English

Resource type - Journals

ISSN - 0793-0291

DOI - 10.1155/mbd.2001.119

Subject(s) - cytotoxicity , in vitro , parasite hosting , pyrimidine , stereochemistry , biology , leishmania , genus , chemistry , biochemistry , botany , world wide web , computer science

The synthesis and characterization of two Pt(II) Complexes with the isomeric ligands 4,5-dihydro-5-oxo- [1,2,4]triazolo-[ 1,5-a]pyrimidine (5HtpO) and 4,7-dihydro-7-oxo-[ 1,2,4]-triazolo-[ 1,5-a]pyrimidine (7HtpO) are described, as well as a Ru(III) complex with 7HtpO. The crystal structure of cis-[PtCl(2)(7HtpO)(2)].2H(2)O has been solved by X-ray diffraction analysis. In vitro activity of the new isolated complexes against the epimastigote form of T. cruzi, procyclic form of T. b. brucei and promastigote form of L. donnovani and P. characias has also been studied. The three complexes markedly affect the growth of the parasites and none of them shows cytotoxicity against macrophage of the J774.2 line at the heaviest dosages used.

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