Zinc(II) Complexes ‐ A New Group of Non‐Mutagenic Herpes Simplex Virus Inhibitors | Zendy

M. Pesheva | Zendy; T. Varadinova | Zendy

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Zinc(II) Complexes ‐ A New Group of Non‐Mutagenic Herpes Simplex Virus Inhibitors

Author(s) -

M. Pesheva,

T. Varadinova

Publication year - 2000

Publication title -

metal-based drugs

Language(s) - English

Resource type - Journals

ISSN - 0793-0291

DOI - 10.1155/mbd.2000.129

Subject(s) - picolinic acid , herpes simplex virus , zinc , chemistry , salmonella , virology , auxotrophy , biology , virus , microbiology and biotechnology , biochemistry , escherichia coli , gene , genetics , bacteria , organic chemistry

Former studies showed that complexes of Zn(II) with picolinic and with aspartic acids, Zn(pic)(2) and Zn(asp)(2), are able to inhibit HSV infection in cultured cells by affecting key steps of virus replication. As these complexes are candidates for a novel class anti-HSV drugs, further studies on their mutagenicity are of particular interest. In the present paper we present data showing that Zn(pic)(2) and Zn(asp)(2) do not express mutagenic effect in both prokaryotic (Salmonella typhimurium) and eukaryotic (Saccharomices cerevisiae) test systems.

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