Synthesis, Spectroscopy and Electrochemistry of Fe(II) and Fe(III)Quinonemonooxime Complexes and Their DNA Cleaving Activities | Zendy

Anupa Murugkar | Zendy; Subhash Padhyé | Zendy; Deepti Deobagkar | Zendy

Open Access

Synthesis, Spectroscopy and Electrochemistry of Fe(II) and Fe(III)Quinonemonooxime Complexes and Their DNA Cleaving Activities

Author(s) -

Anupa Murugkar,

Subhash Padhyé,

Deepti Deobagkar

Publication year - 1999

Publication title -

metal-based drugs

Language(s) - English

Resource type - Journals

ISSN - 0793-0291

DOI - 10.1155/mbd.1999.81

Subject(s) - electrochemistry , spectroscopy , chemistry , dna , inorganic chemistry , nuclear chemistry , electrode , biochemistry , physics , quantum mechanics

Iron(II) and iron(III) complexes of 3,5-di-tert-butyl-o-benzoquinonemonooxime were synthesized and characterized by spectroscopic and electrochemical studies. Their ability to cleave DNA has been investigated under aerobic conditions at room temperature and in the presence and absence of H(2) O(2). The plasmid DNA pBR322 was effectively cleaved by these complexes in a concentration dependant manner.

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