Ni (II), Cu (II) and Zn (II) Metal Chelates With Some ThiazoleDerived Schiff‐Bases: Their Synthesis, Characterization andBactericidal Properties | Zendy

Zahid H. Chohan | Zendy

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Ni (II), Cu (II) and Zn (II) Metal Chelates With Some ThiazoleDerived Schiff‐Bases: Their Synthesis, Characterization andBactericidal Properties

Author(s) -

Zahid H. Chohan

Publication year - 1999

Publication title -

metal-based drugs

Language(s) - English

Resource type - Journals

ISSN - 0793-0291

DOI - 10.1155/mbd.1999.75

Subject(s) - thiazole , chelation , chemistry , salicylaldehyde , schiff base , metal , octahedron , antibacterial activity , nuclear chemistry , stereochemistry , polymer chemistry , medicinal chemistry , inorganic chemistry , crystallography , organic chemistry , bacteria , crystal structure , biology , genetics

A number of thiazole derived tridentate Schiff-bases (LH) and its metal chelates of the type [M(L)(2)X] where M=Ni(II), Cu(II) and Zn(II), L=substituted salicylaldehyde (5-H, 5-CH(3), 5-OCH(3), 5-NO(2) and 5-Cl) and X=CI have been synthesized and characterized with the help of elemental analyses, conductivity measurements, magnetic moments, UV-Vis, IR and NMR spectral data. An octahedral structure for Ni(II) and Zn(II) and a distorted octahedral structure for Cu(II) chelates have been proposed. All the Schiff-bases and their metal chelates have been screened for their biological activity against Escherichia coli, Staphylococcus aureous , Pseudomonas aeruginosa and Klebsiella pneumonae and in comparison, the metal chelates have been shown to possess more antibacterial activity than the uncomplexed Schiff-bases.

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