A 5′-Phosphodiester Group Attached to Deoxyguanosine does not Accelerate the Hydrolysis of cis-[PtCl(NH3 | Zendy

Tiphaine Weber | Zendy; Franck Legendre | Zendy; Veronika Novozamsky | Zendy; Jiřı́ Kozelka | Zendy

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A 5′-Phosphodiester Group Attached to Deoxyguanosine does not Accelerate the Hydrolysis of cis-[PtCl(NH3

Author(s) -

Tiphaine Weber,

Franck Legendre,

Veronika Novozamsky,

Jiřı́ Kozelka

Publication year - 1998

Publication title -

metal-based drugs

Language(s) - English

Resource type - Journals

ISSN - 0793-0291

DOI - 10.1155/mbd.1999.5

Subject(s) - group (periodic table) , chemistry , organic chemistry

The influence of the methylphosphoester group on the reversible reaction shown below was studied. Evaluation of the rate constants for the system depicted as well as for the analogous equilibrium involving the nucleoside deoxyguanosine showed that whereas the chloride anation is slowed down by the presence of the methylphosphoester group, the hydrolysis rate constant is not significantly altered. This result speaks against a catalytic role of the 5’-phosphodiester group in the hydrolysis of cisplatin monoadducts with DNA, as suggested previously (Kozelka & Barre, Chem. Eur. J. 1997, 3, 1405-1409). NH3

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