Hormone Anchored Metal Complexes. 1. Synthesis, Structure,Spectroscopy and In Vitro Antitumor Activity of TestosteroneAcetate Thiosemicarbazone and its Metal Complexes | Zendy

Anupa Murugkar | Zendy; Bindu Unnikrishnan | Zendy; Subhash Padhyé | Zendy; Ramesh Bhonde | Zendy; Simon J. Teat | Zendy; Evangelia Triantafillou | Zendy; Ekkehard Sinn | Zendy

Open Access

Hormone Anchored Metal Complexes. 1. Synthesis, Structure,Spectroscopy and In Vitro Antitumor Activity of TestosteroneAcetate Thiosemicarbazone and its Metal Complexes

Author(s) -

Anupa Murugkar,

Bindu Unnikrishnan,

Subhash Padhyé,

Ramesh Bhonde,

Simon J. Teat,

Evangelia Triantafillou,

Ekkehard Sinn

Publication year - 1999

Publication title -

metal-based drugs

Language(s) - English

Resource type - Journals

ISSN - 0793-0291

DOI - 10.1155/mbd.1999.177

Subject(s) - algorithm , chemistry , computer science

Testosterone acetate thiosemicarbazone (TATSC, 17-beta-hydroxyandrost-4-one acetate thiosemicarbazone) was synthesized and characterized by single crystal X-ray structure determination. The copper and platinum complexes of this steroid derivative were synthesized and characterized by spectroscopy and electrochemiatry. The in vitro activity of these compounds against human breast cancer cell line MCF-7 was tested. The highest activity was found for the [Pt(TATSC)Cl(1)] followed by [Cu(TATSC)Cl(2)] and the ligand in compariosn with cisplatin.

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