Synthesis and Characterization of Coordinatively Unsaturated Copper(II) Complexes of 1,3‐Bis(2′‐Pyridyl)‐1,2‐Diaza‐2‐Butene and TheirAntityrosinase Activity | Zendy

Ratnamala S. Bendre | Zendy; Anupa Murugkar | Zendy; Subhash Padhyé | Zendy; Pallavi Kulkarni | Zendy; Meena Karve | Zendy

Open Access

Synthesis and Characterization of Coordinatively Unsaturated Copper(II) Complexes of 1,3‐Bis(2′‐Pyridyl)‐1,2‐Diaza‐2‐Butene and TheirAntityrosinase Activity

Author(s) -

Ratnamala S. Bendre,

Anupa Murugkar,

Subhash Padhyé,

Pallavi Kulkarni,

Meena Karve

Publication year - 1997

Publication title -

metal-based drugs

Language(s) - English

Resource type - Journals

ISSN - 0793-0291

DOI - 10.1155/mbd.1998.59

Subject(s) - copper , chemistry , tyrosinase , 1 butene , stereochemistry , medicinal chemistry , enzyme , polymer chemistry , catalysis , organic chemistry

The coordinatively unsaturated copper (II) complexes of 1,3-bis(2'-pyridyl)-1,2-diaza-2- butene with different ancillary anions were synthesized which can bind to copper centers of tyrosinase enzyme. The compounds were found to exhibit inhibitory activities against mushroom tyrosinase and the nature and extent of inhibition is modulated according to the type of ancillary anions.

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