Pd(II) and Pt(II) Complexes of Schiff Thiobases Derived From2‐Carbonylpyridine | Zendy

M. Gómez-Bosquet | Zendy; Vı́ctor Moreno | Zendy; Mercè FontBardía | Zendy; X. Soláns | Zendy

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Pd(II) and Pt(II) Complexes of Schiff Thiobases Derived From2‐Carbonylpyridine

Author(s) -

M. Gómez-Bosquet,

Vı́ctor Moreno,

Mercè FontBardía,

X. Soláns

Publication year - 1998

Publication title -

metal-based drugs

Language(s) - English

Resource type - Journals

ISSN - 0793-0291

DOI - 10.1155/mbd.1998.161

Subject(s) - chemistry , imine , ligand (biochemistry) , derivative (finance) , dna , adduct , schiff base , stereochemistry , chloride , ion , crystallography , sulfur , crystal structure , medicinal chemistry , polymer chemistry , organic chemistry , catalysis , receptor , biochemistry , financial economics , economics

Pd(ll) and Pt(ll) complexes of three series of Schiff thiobases derived from 2- carbonylpyridine have been synthesized and characterized. The crystal structure of the Pt(ll) derivative of methyl-3-(2-pyridylmethylene)hydrazinecarbodithioate (HFp) was resolved. The ligand coordinates the platinum ion in tridentate fashion by heterocycle and imine nitrogen and thiocarbonyl sulfur. The fourth ligand is a chloride ion. The structure of the complexes is suitable for the formation of monofunctional adducts with DNA. Studies on the interaction of the complexes with Calf thymus DNA by CD reveal modifications in the B form of lineal DNA. Interaction with plasmid DNA was also confirmed in the images obtained by atomic force microscopy.

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