Distribution of Rhodium in Mice Submitted to Treatment With the Adduct of Rhodium Propionate and Sodium Isonicotinate | Zendy

Aparecido Ribeiro de Souza | Zendy; Renato Najjar | Zendy; Elizabeth de Oliveira | Zendy; Szulim Ber Zyngier | Zendy

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Distribution of Rhodium in Mice Submitted to Treatment With the Adduct of Rhodium Propionate and Sodium Isonicotinate

Author(s) -

Aparecido Ribeiro de Souza,

Renato Najjar,

Elizabeth de Oliveira,

Szulim Ber Zyngier

Publication year - 1997

Publication title -

metal-based drugs

Language(s) - English

Resource type - Journals

ISSN - 0793-0291

DOI - 10.1155/mbd.1997.39

Subject(s) - rhodium , spleen , ovary , kidney , propionate , adduct , chemistry , intraperitoneal injection , uterus , medicine , biochemistry , catalysis , organic chemistry

The distribution of rhodium in Balb/c mice following intraperitoneal (ip) administration of a solution of adduct of rhodium propionate and sodium isonicotinate has been investigated. The metal concentration was determined in blood and in the following organ tissues: brain, heart, lung, liver, spleen, kidney, testes, and uterus/ovary, and the rhodium concentration was obtained by Inductively Coupled Argon Atomic Emission Spectroscopy (ICP-AES). The metal was detected in all organ tissues examined, mainly in spleen, liver, uterus/ovary and heart. Nine days after the injection, traces of rhodium were found in the liver and kidneys and, twenty days after the injection, only in the liver.

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