Reactions of Pd(II) and Pt(II) Complexes With Tetraethylthiouram Disulfide

The reactions of tetraethylthiouram disulfide (DTS), an inhibitor of the nephrotoxicity of Pt(II) drugs, an efficient agent in the treatment of chronic alcoholism, in the treatment of HIV infections, AIDS and heavy metal toxicity, and a fungicide and herbicide, with K(2)[PtCl(4)], in ratio 1:1 and 1:2, gave the compounds [PtCl(2)DTS] and [Pt(S(2)CNEt(2))(2)] respectively. The reaction of the complexes K(2)[PdCl(4)], Pd(AcO)(2) and [PdCl(2)(PhCN)(2)], where PhCN = Benzonitrile, with tetraethylthiouram disulfide in ratio 1:1 or 1:2, yielded orange crystals identified as [Pd(S(2)CNEt(2))(2)]. The crystals were suitable for study by X-ray diffraction. The -S-S- bridge in the tetraethylthiouram disulfude molecule was broken and the two molecules of the thiocarbamate derivative were bound to the Pd(II) by the equivalents sulfur atoms. All the compounds were characterized by IR, (1)H and (13)C NMR spectroscopies.