Carbonic Anhydrase Inhibitors. Part 461 Inhibition of Carbonic Anhydrase Isozymes I, II and IV With Trifluoromethylsulfonamide Derivatives and Their Zinc(II) and Copper(II) Complexes | Zendy

Giovanna Mincione | Zendy; Andrea Scozzafava | Zendy; Claudiu T. Supuran | Zendy

Open Access

Carbonic Anhydrase Inhibitors. Part 46¹ Inhibition of Carbonic Anhydrase Isozymes I, II and IV With Trifluoromethylsulfonamide Derivatives and Their Zinc(II) and Copper(II) Complexes

Author(s) -

Giovanna Mincione,

Andrea Scozzafava,

Claudiu T. Supuran

Publication year - 1997

Publication title -

metal-based drugs

Language(s) - English

Resource type - Journals

ISSN - 0793-0291

DOI - 10.1155/mbd.1997.27

Subject(s) - carbonic anhydrase , chemistry , thermogravimetric analysis , carbonic anhydrase ii , algorithm , mathematics , organic chemistry , enzyme

Reaction of aromatic/heterocyclic sulfonamides containing a free amino group with triflic anhydride afforded compounds possessing trifluoromethanesulfonamido moieties in their molecule. The Zn(II) and Cu(II) complexes of these new sulfonamides were prepared and characterized by standard procedures (elemental analysis, spectroscopic, magnetic, thermogravimetric and conductimetric measurements). The new derivatives showed good inhibitory activity against three isozymes of carbonic anhydrase (CA), i.e., CA I, II and IV.

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