Complexes With Biologically Active Ligands. Part 101 Inhibition of Carbonic Anhydrase Isozymes I and II With Metal Complexes of Imidazo[2,1−b] | Zendy

Andrea Scozzafava | Zendy; Claudiu T. Supuran | Zendy

Open Access

Complexes With Biologically Active Ligands. Part 101 Inhibition of Carbonic Anhydrase Isozymes I and II With Metal Complexes of Imidazo[2,1−b]

Author(s) -

Andrea Scozzafava,

Claudiu T. Supuran

Publication year - 1997

Publication title -

metal-based drugs

Language(s) - English

Resource type - Journals

ISSN - 0793-0291

DOI - 10.1155/mbd.1997.19

Subject(s) - metal , carbonic anhydrase , chemistry , metal ions in aqueous solution , electron paramagnetic resonance , nuclear chemistry , physics , nuclear magnetic resonance , enzyme , organic chemistry

THE TITLE COMPOUND WAS PREPARED BY AN IMPROVED VARIANT OF THE LITERATURE PROCEDURE, AND METAL COMPLEXES CONTAINING ITS ANION AND THE FOLLOWING METAL IONS: Zn(II), Cd(II), Hg(II), Co(II), Ni(II), Cu(II), V(IV), Fe(III) and Ag(I) were synthesized and characterized by standard procedures (elemental analysis; IR, electronic, NMR and EPR spectroscopy; TG, magnetic and conductimetric measurements). The parent sulfonamide and its metal complexes are potent inhibitors of two carbonic anhydrase (CA) isozymes, CA I and II, and they might possess applications as selective cerebrovasodilating agents.

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