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THE TITLE COMPOUND WAS PREPARED BY AN IMPROVED VARIANT OF THE LITERATURE PROCEDURE, AND METAL COMPLEXES CONTAINING ITS ANION AND THE FOLLOWING METAL IONS: Zn(II), Cd(II), Hg(II), Co(II), Ni(II), Cu(II), V(IV), Fe(III) and Ag(I) were synthesized and characterized by standard procedures (elemental analysis; IR, electronic, NMR and EPR spectroscopy; TG, magnetic and conductimetric measurements). The parent sulfonamide and its metal complexes are potent inhibitors of two carbonic anhydrase (CA) isozymes, CA I and II, and they might possess applications as selective cerebrovasodilating agents.

metal-based drugs

Complexes With Biologically Active Ligands. Part <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:msup><mml:mn>10</mml:mn><mml:mn>1</mml:mn></mml:msup></mml:math> Inhibition of Carbonic Anhydrase Isozymes I and II With Metal Complexes of Imidazo<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mrow><mml:mrow><mml:mo>[</mml:mo><mml:mrow><mml:mn>2</mml:mn><mml:mo>,</mml:mo><mml:mn>1</mml:mn><mml:mo>−</mml:mo><mml:mi>b</mml:mi></mml:mrow><mml:mo>]</mml:mo></mml:mrow></mml:…

Complexes With Biologically Active Ligands. Part 101 Inhibition of Carbonic Anhydrase Isozymes I and II With Metal Complexes of Imidazo[2,1−b]