Complexes With Biologically Active Ligands. Part 4. CoordinationCompounds of Chlorothiazide With Transition Metal Ions Behave asStrong Carbonic Anhydrase Inhibitors | Zendy

Claudiu T. Supuran | Zendy

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Complexes With Biologically Active Ligands. Part 4. CoordinationCompounds of Chlorothiazide With Transition Metal Ions Behave asStrong Carbonic Anhydrase Inhibitors

Author(s) -

Claudiu T. Supuran

Publication year - 1996

Publication title -

metal-based drugs

Language(s) - English

Resource type - Journals

ISSN - 0793-0291

DOI - 10.1155/mbd.1996.79

Subject(s) - benzothiadiazine , chlorothiazide , carbonic anhydrase , chemistry , acetazolamide , derivative (finance) , thermogravimetric analysis , inorganic chemistry , isozyme , medicinal chemistry , enzyme , diuretic , biochemistry , organic chemistry , pharmacology , medicine , anesthesia , financial economics , economics

Complexes of the diuretic benzothiadiazine derivative chlorothiazide (6-chloro-7-sulfamoyl- 1,2,4-benzothiadiazine-1,1-dioxide) with V(IV); Fe(II); Co(II); Ni(II); Cu(II), Ag(I) and U(VI) were prepared and characterized by elemental analysis, spectroscopic, thermogravimetric, magnetic and conductimetric measurements. The complexes behave as effective inhibitors for two isozymes (I and II) of carbonic anhydrase (CA).

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