Anti‐Tumor Activity, In Vitro and In Vivo, of SomeTriphenylphosphinegold(I) Thionucleobases | Zendy

Lorraine K. Webster | Zendy; Silvina Rai | Zendy; Ernst Horn | Zendy; Edward R. T. Tiekink | Zendy

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Anti‐Tumor Activity, In Vitro and In Vivo, of SomeTriphenylphosphinegold(I) Thionucleobases

Author(s) -

Lorraine K. Webster,

Silvina Rai,

Ernst Horn,

Edward R. T. Tiekink

Publication year - 1996

Publication title -

metal-based drugs

Language(s) - English

Resource type - Journals

ISSN - 0793-0291

DOI - 10.1155/mbd.1996.63

Subject(s) - in vivo , in vitro , chemistry , mathematics , biology , biochemistry , microbiology and biotechnology

The [Ph(3)PAu(6-MP)] complex, where 6-MPH is 6-mercaptopurine, is active against the cisplatinresistant cell line, mouse leukaemia L1210/DDP, as is the precursor compound [Ph(3)PAuCl], suggesting that the thiolate is not critical for activity. Against the human cell lines, FaDu (squamous cell carcinoma) and SKOV-3 (ovarian carcinoma), both [Ph(3)PAu(6-MP)] and [Ph(3)PAu(6-TG)], where 6-TGH is 6-thioguanine, were active. [Ph(3)PAu(6-MP)] was active against a murine PC6 plasmacytoma, but not as active as cisplatin.

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