Complexes With Biologically Active Ligands. Part 61 Ni(II)Coordination Compounds of Hydrazine and Heterocyclic Sulfonamidesas Inhibitors of the Zinc Enzyme Carbonic Anhydrase | Zendy

J. Borrás | Zendy; Javier Casanova | Zendy; Teodora Cristea | Zendy; Adriana Gheorghe | Zendy; Andrea Scozzafava | Zendy; Claudiu T. Supuran | Zendy; Violeta Tudor | Zendy

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Complexes With Biologically Active Ligands. Part 6¹ Ni(II)Coordination Compounds of Hydrazine and Heterocyclic Sulfonamidesas Inhibitors of the Zinc Enzyme Carbonic Anhydrase

Author(s) -

J. Borrás,

Javier Casanova,

Teodora Cristea,

Adriana Gheorghe,

Andrea Scozzafava,

Claudiu T. Supuran,

Violeta Tudor

Publication year - 1996

Publication title -

metal-based drugs

Language(s) - English

Resource type - Journals

ISSN - 0793-0291

DOI - 10.1155/mbd.1996.143

Subject(s) - carbonic anhydrase , chemistry , hydrazine (antidepressant) , thermogravimetric analysis , zinc , enzyme , isozyme , elemental analysis , carbonic anhydrase i , active site , inorganic chemistry , medicinal chemistry , nuclear chemistry , organic chemistry , biochemistry

Ternary Ni(II) complexes of hydrazine and eight heterocyclic sulfonamides possessing carbonic anhydrase (CA) inhibitory properties, were prepared and characterized by elemental analysis, spectroscopic, magnetic, thermogravimetric, and conductimetric measurements. The complexes behave as strong inhibitors for two isozymes (I and II) of carbonic anhydrase.

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