Open AccessNew Perfluorophtalate Complexes of Platinum(II) With Chemotherapeutic Potential
Author(s) -
M. B. de Oliveira,
Joseph Miller,
R. E. BANKS,
Lloyd R. Kèlland,
Charles A. McAuliffe,
Naheed Mahmood,
Ian J. Rowland
Publication year - 1995
Publication title -
metal-based drugs
Language(s) - English
Resource type - Journals
ISSN - 0793-0291
DOI - 10.1155/mbd.1996.117
Subject(s) - platinum , morpholine , piperidine , chemistry , human immunodeficiency virus (hiv) , stereochemistry , medicinal chemistry , virology , medicine , biochemistry , catalysis
Two new platinum(II) complexes have been synthesized and their anti-tumour and anti-HIV activities have been evaluated.THE NEW COMPLEXES ARE: (i) cis-tetrafluorophthalate-ammine-morpholine-platinum(II) or MMF3 and (ii) cis-tetrafluorophthalate- ammine-piperidine-platinum(II) or MPF4. They were characterized by elemental analysis, IR spectra and (1)H and (13)C NMR spectra.They were tested against five human ovarian carcinoma cell lines, viz., CH1, CH1cisR, A2780, A2780cisR and SKOV-3. They were less active than cis-platin and showed cross-resistance with cis-platin in the CH1cisR and A2780cisR acquired resistance lines.They were also tested for possible anti-HIV activity using the HIV-I IIIB virus and C8166 cells, but they were inactive compared with AZT.
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