Thienothiopyransulfonamides as Complexing Agents for the Preparation of Dual Carbonic Anhydrase Inhibitors | Zendy

Claudiu T. Supuran | Zendy

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Thienothiopyransulfonamides as Complexing Agents for the Preparation of Dual Carbonic Anhydrase Inhibitors

Author(s) -

Claudiu T. Supuran

Publication year - 1995

Publication title -

metal-based drugs

Language(s) - English

Resource type - Journals

ISSN - 0793-0291

DOI - 10.1155/mbd.1995.327

Subject(s) - carbonic anhydrase , sulfonamide , chemistry , isozyme , enzyme , chelation , carbonic anhydrase i , combinatorial chemistry , carbonic anhydrase ii , acetazolamide , nuclear chemistry , inorganic chemistry , biochemistry , medicinal chemistry , stereochemistry , medicine

Co(II); Zn(II) and Cu(II) complexes of two new sulfonamide carbonic anhydrase (CA) inhibitors, derivatives of thienothiopyran-2-sulfonamide, were prepared and characterized by analytic, spectroscopic, magnetic and conductimetric measurements. The new complexes are more potent CA inhibitors than the parent sulfonamides, with IC(50) values around 0.1 nM, against isozyme CA II.

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