On the Mechanism of Action of the Antitumor Drug cis‐Platin(cis‐DDP) and its Second Generation Derivatives

The present article attempts to summarise the elements of the mechanism of action of the antitumor drug cis -Platin presented the last few years. Highlights on the discovery, of the drug and the development of it's second generation derivatives are presented, as well as the ways that cis -DDP reacts with biomolecules as DNA and proteins and their models e.g. nucleosides, nucleotides. Also the hydrolysis data are presented for cis -DDP and its' inactive congener trans -DDP, as well as for the second generation drug carboplatin. Finally, usefull conclusions are given from this work, pointing out the unanswered questions about the action of cis -DDP as well as its differences in action, in comparison with trans -DDP.