UVA-Photosensitivity of cis-Diamminedichloro-Platinum(II)-Modified DNA | Zendy

Dominique PayetBornet | Zendy; Marc Leng | Zendy

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UVA-Photosensitivity of cis-Diamminedichloro-Platinum(II)-Modified DNA

Author(s) -

Dominique PayetBornet,

Marc Leng

Publication year - 1995

Publication title -

metal-based drugs

Language(s) - English

Resource type - Journals

ISSN - 0793-0291

DOI - 10.1155/mbd.1995.137

Subject(s) - photosensitivity , oligonucleotide , adduct , chemistry , platinum , cleavage (geology) , cross link , dna , irradiation , stereochemistry , materials science , biochemistry , catalysis , organic chemistry , polymer , physics , optoelectronics , fracture (geology) , nuclear physics , composite material

cis-Diamminedichloroplatinum(II)-modified oligonucleotides contain-ing either a single intrastrand cross-link at the d(GpG) site or an interstrand cross-link at the d(GpC/GpC) site, were irradiated with 320 to 400-nm light. Upon irradiation, the adducts are photosensitive. Among the photo-induced reactions, the cleavage of the coordination bonds between platinum and the G residues in the interstrand cross-link is demonstrated.

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