Open AccessInteraction of Gold With Red Blood Cells
Author(s) -
Yafei Zhang,
Evelyn V. Hess,
Keith G. Pryhuber,
John G. Dorsey,
Katherine Tepperman,
R. C. Elder
Publication year - 1994
Publication title -
metal-based drugs
Language(s) - English
Resource type - Journals
ISSN - 0793-0291
DOI - 10.1155/mbd.1994.517
Subject(s) - art , chemistry
Gold compounds are among the few therapeutic agents that can cause remission of aggressive rheumatoid arthritis. Although the mechanism for their toxicity and efficacy is unknown, gold levels in blood have been emphasized recently. In this report, we describe a systematic method to study the gold interaction with red blood cells and its distribution in the cell. Flow injection analysis (FIA) and high performance liquid chromatography HPLC) with gold-specific inductively coupled plasma-mass spectrometry (ICP-MS) detection are used.
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