Synthesis, Characterization and High In Vitro Antitumour Activityof Novel Triphenyltin Carboxylates | Zendy

Marcel Gielen | Zendy; Abdelaziz El Khloufi | Zendy; Monique Biesemans | Zendy; Abdeslam Bouhdid | Zendy; Dick de Vos | Zendy; Bernard Mahieu | Zendy; Rudolph Willem | Zendy

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Synthesis, Characterization and High In Vitro Antitumour Activityof Novel Triphenyltin Carboxylates

Author(s) -

Marcel Gielen,

Abdelaziz El Khloufi,

Monique Biesemans,

Abdeslam Bouhdid,

Dick de Vos,

Bernard Mahieu,

Rudolph Willem

Publication year - 1994

Publication title -

metal-based drugs

Language(s) - English

Resource type - Journals

ISSN - 0793-0291

DOI - 10.1155/mbd.1994.305

Subject(s) - in vitro , etoposide , chemistry , doxorubicin , mitomycin c , cancer research , cell culture , carcinoma cell , stereochemistry , biochemistry , biology , chemotherapy , genetics

The synthesis and spectral characterization of six novel triphenyltin compounds are described. The in vitro antitumour activity of three of these compounds against two human tumour cell lines, MCF-7, a mammary tumour, and WiDr, a colon carcinoma, was determined. All three compounds are more active than cis-platin, etoposide and doxorubicin against both tumour cell lines. They are as active as mitomycin C against WiDr, but less active against MCF-7.

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