In Vitro Antitumour Activity of Some Triorganophosphinegold(I) Thionucleobases | Zendy

Edward R. T. Tiekink | Zendy; Peter D. Cookson | Zendy; Bernadette Μ. Linahan | Zendy; Lorraine K. Webster | Zendy

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In Vitro Antitumour Activity of Some Triorganophosphinegold(I) Thionucleobases

Author(s) -

Edward R. T. Tiekink,

Peter D. Cookson,

Bernadette Μ. Linahan,

Lorraine K. Webster

Publication year - 1994

Publication title -

metal-based drugs

Language(s) - English

Resource type - Journals

ISSN - 0793-0291

DOI - 10.1155/mbd.1994.299

Subject(s) - in vitro , chemistry , biochemistry

A series of phosphinegold(I) thionucleobase analogues, [R(3)PAu(SR(x))] (R = Et, Ph or chexyl; HSR(1) = 2-mercaptobenzoic acid, HSR(2) = 2-thiouracil, HSR(3) = 6-mercaptopurine and HSR(4) = 6-thioguanine) have been examined for their in vitro cytotoxicity in L1210 murine leukemia cells in culture. The range of ID(50) values (continuous 48 h exposure) for the complexes is 0.041 - 0.131 muM. The complexes with SR(3) and SR(3) are generally the most active; however, there is no clear trend associated with the phosphine ligands.

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