Open AccessLinks Between Repeated Sequences
Author(s) -
Sachiko Matsutani
Publication year - 2006
Publication title -
biomed research international
Language(s) - English
Resource type - Journals
eISSN - 2314-6141
pISSN - 2314-6133
DOI - 10.1155/jbb/2006/13569
Subject(s) - retrotransposon , pseudogene , alu element , biology , genetics , genome , signal recognition particle rna , rna polymerase iii , human genome , transfer rna , gene , rna , ribosomal rna , computational biology , rna binding protein , transposable element , rna polymerase
L1 and Alu elements are long and short interspersedretrotransposable elements (LINEs and SINEs) in humans,respectively. Proteins encoded in the autonomous L1 mediateretrotransposition of the nonautonomous Alu and cellularmRNAs. Alu is the only active SINE in the human genomeand is derived from 7SL RNA of signal recognition particle. In theother eukaryotic genomes, various tRNA- and 5S rRNA-derived SINEsare found. Some of the tRNA- and 5S rRNA-derived SINEs havepartner LINEs of which 3' sequences are similar to those of theSINEs. One of the tRNA-derived SINEs is shown to be mobilized byits partner LINE. Many copies of tRNA and 5S rRNA pseudogenes arepresent in the human genome. These pseudogenes may have beengenerated via the retrotransposition process using L1 proteins.Although there are no sequence similarities between L1 andAlu, L1 functionally links with Alu and evencellular genes, impacting on our genome shaping
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