Interplay Between Oxidative Damage, Protein Synthesis, and ProteinDegradation in Alzheimer′s Disease

Protein synthesis and protein degradation are highly regulatedcellular processes that are essential to maintaining cellviability. Numerous studies now indicate that protein synthesisand protein degradation are significantly altered in Alzheimer'sdisease (AD), with impairments in these two processes potentiallycontributing to AD pathogenesis. Alterations in steady stateprotein regulation may be a particularly important factor inregulating whether cells maintain homeostasis in response tooxidative damage, or conversely whether oxidative stress isinduced by oxidative damage. The focus of this review is todiscuss recent findings on each of these topics, and to discusstheir importance to the onset and progression of AD