Protective Effect ofMeso-Tetrakis-(3,5-di-tert- butyl-4-hydroxyphenyl)porphyrin on the In Vivo Impact of Trimethyltin Chloride on the Antioxidative Defense System | Zendy

Е. Р. Милаева | Zendy; V. Yu. Tyurin | Zendy; Yulia A. Gracheva | Zendy; Margarita A. Dodochova | Zendy; Lydia M. Pustovalova | Zendy; Victor N. Chernyshev | Zendy

Open Access

Protective Effect ofMeso-Tetrakis-(3,5-di-tert- butyl-4-hydroxyphenyl)porphyrin on the In Vivo Impact of Trimethyltin Chloride on the Antioxidative Defense System

Author(s) -

Е. Р. Милаева,

V. Yu. Tyurin,

Yulia A. Gracheva,

Margarita A. Dodochova,

Lydia M. Pustovalova,

Victor N. Chernyshev

Publication year - 2006

Publication title -

bioinorganic chemistry and applications

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.865

H-Index - 35

eISSN - 1565-3633

pISSN - 1687-479X

DOI - 10.1155/bca/2006/64927

Subject(s) - catalase , superoxide dismutase , porphyrin , chemistry , in vivo , free base , enzyme , medicinal chemistry , chloride , nuclear chemistry , biochemistry , organic chemistry , salt (chemistry) , biology , microbiology and biotechnology

The in vivo effect of trimethyltin chloride (Me 3 SnCl), free base meso -tetrakis(3,5-di- tert -butyl-4-hydroxyphenyl)porphyrin (R′ 4 PH 2 ) and their equimolar mixture, on the enzymatic activity of catalase (CAT), superoxide dismutase (SOD), and on the total content of free sulfhydryl groups has been studied in rat liver and kidney. It was demonstrated that the simultaneous treatment of tested animals with the combination of Me 3 SnCl and R′ 4 PH 2 reduced the toxic impact of Me 3 SnCl.

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