Kinetic Study of DNA Modification by Phthalocyanine Derivative of the Oligonucleotide | Zendy

А. А. Кузнецова | Zendy; Alexander А. Cherosov | Zendy; Nikita A. Kuznetsov | Zendy; Vladimir V. Koval | Zendy; D.G. Knorre | Zendy; Olga S. Fedorova | Zendy

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Kinetic Study of DNA Modification by Phthalocyanine Derivative of the Oligonucleotide

Author(s) -

А. А. Кузнецова,

Alexander А. Cherosov,

Nikita A. Kuznetsov,

Vladimir V. Koval,

D.G. Knorre,

Olga S. Fedorova

Publication year - 2006

Publication title -

bioinorganic chemistry and applications

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.865

H-Index - 35

eISSN - 1565-3633

pISSN - 1687-479X

DOI - 10.1155/bca/2006/23560

Subject(s) - oligonucleotide , phthalocyanine , hydrogen peroxide , chemistry , kinetics , dna , catalysis , combinatorial chemistry , chemical modification , oxygen , reactive oxygen species , photochemistry , polymer chemistry , biochemistry , organic chemistry , physics , quantum mechanics

Design of chemically modified oligonucleotides for regulation of gene expression has attracted considerable attention over the last decades. One actively pursued approach involves antisense or antigene constructs carrying reactive groups, many of these based on transition metal complexes. The complexes of Co(II) with phthalocyanines are extremely good catalysts of oxidation of organic compounds with molecular oxygen and hydrogen peroxide. In this study, we have investigated the kinetics and thermodynamics of sequence-specific modification of DNA with deoxyribooligonucleotide linked to Co(II)-tetracarboxyphthalocyanine (PtcCo(II)) in the presence of H 2 O 2 .

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