Bioinorganic Chemistry in Thyroid Gland: Effect of Antithyroid Drugs on Peroxidase‐Catalyzed Oxidation and Iodination Reactions | Zendy

Gouriprasanna Roy | Zendy; Govindasamy Mugesh | Zendy

Open Access

Bioinorganic Chemistry in Thyroid Gland: Effect of Antithyroid Drugs on Peroxidase‐Catalyzed Oxidation and Iodination Reactions

Author(s) -

Gouriprasanna Roy,

Govindasamy Mugesh

Publication year - 2006

Publication title -

bioinorganic chemistry and applications

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.865

H-Index - 35

eISSN - 1565-3633

pISSN - 1687-479X

DOI - 10.1155/bca/2006/23214

Subject(s) - lactoperoxidase , chemistry , propylthiouracil , thyroid , thyroid peroxidase , antithyroid agent , iodine , hormone , thyroglobulin , selenium , bioinorganic chemistry , iodide , halogenation , peroxidase , medicine , endocrinology , biochemistry , graves' disease , enzyme , organic chemistry

Propylthiouracil (PTU) and methimazole (MMI) are the most commonly used antithyroid drugs. The available data suggest that these drugs may block the thyroid hormone synthesis by inhibiting the thyroid peroxidase (TPO) or diverting oxidized iodides away from thyroglobulin. It is also known that PTU inhibits the selenocysteine-containing enzyme ID-1 by reacting with the selenenyl iodide intermediate (E-SeI). In view of the current interest in antithyroid drugs, we have recently carried out biomimetic studies to understand the mechanism by which the antithyroid drugs inhibit the thyroid hormone synthesis and found that the replacement of sulfur with selenium in MMI leads to an interesting compound that may reversibly block the thyroid hormone synthesis. Our recent results on the inhibition of lactoperoxidase (LPO)-catalyzed oxidation and iodination reactions by antithyroid drugs are described.

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