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Triphenylantimony(V) derivative,  Ph 3 Sb(OPr i ) [SC 6 H 4 N : C(CH 3 )CH 2 C(O)CH 3 ] ,  1b , and the corresponding benzothiazoline ligand [ 1 ,  2 ],    HNC   6    H  4   SC   ⎴   (    CH   3   )    CH   2   C  (  O  )    CH   3    ,  1a , have been tested for their effects on the reproductive system of male albino rats. The oral administration of both  1a  and  1b  at the dose level of 10 mg/rat/day produced significant reduction in the weights of testes, epididymides, seminal vesicles, and ventral prostate. Significant decrease in sperm motility as well as in sperm density resulted in 100% sterility. Significant ( P  < .01) alterations were also found in biochemical parameters of reproductive organs in treated male rats as compared to the control group. Production of preleptotene, pachytene, and secondary spermatocytes was decreased by 42%, 43%, 39%, and by 44%, 49%, 55% in the ligand,  1a , and organoantimony(V) derivative,  1b , treated rats, respectively. These results indicate that both compounds  1a  and  1b  are antispermatogenic in nature and on oral administration in male rats, and finally caused sterility. A comparison indicates that the organoantimony(V) derivative  1b  is more effective pertaining to its antispermatogenic activity than the corresponding ligand  1a .

Antispermatogenic Activity of the Benzothiazoline Ligand and Corresponding Organoantimony(V) Derivative in Male Albino Rats