Prognostic Role of Tumor Microenvironment in DLBCL and Relation to Patients’ Clinical Outcome: A Clinical and Immunohistochemical Study | Zendy

Doaa Shams-Deen Ghorab | Zendy; Ahmed Mohamed Helaly | Zendy; Hoda Saleh El Mahdi | Zendy; Moawiah Khatatbeh | Zendy; Afaf T. Ibrahiem | Zendy

Open Access

Prognostic Role of Tumor Microenvironment in DLBCL and Relation to Patients’ Clinical Outcome: A Clinical and Immunohistochemical Study

Author(s) -

Doaa Shams-Deen Ghorab,

Ahmed Mohamed Helaly,

Hoda Saleh El Mahdi,

Moawiah Khatatbeh,

Afaf T. Ibrahiem

Publication year - 2022

Publication title -

analytical cellular pathology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.576

H-Index - 24

eISSN - 2210-7185

pISSN - 2210-7177

DOI - 10.1155/2022/9993496

Subject(s) - cd68 , immunohistochemistry , tumor microenvironment , stroma , lymphoma , cd163 , medicine , tumor associated macrophage , pathology , cancer research , cd8 , immune system , macrophage , biology , tumor cells , immunology , in vitro , biochemistry

Diffuse large B cell lymphoma is the most common type of lymphoma in Egypt with an unfavorable prognosis. The tumor microenvironment is rich in immune response either T cells or macrophages. The current study is aimed at testing CD4, CD8, CD68, and MMP9 immunohistochemistry of DLBCL activities with the prognosis of the tumor. The results showed no positive relation between T cell and macrophage reaction to the tumor prognosis suggesting that this reaction is part of the tumor process and not a defense mechanism from the surrounding stroma.

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