Dracorhodin Perchlorate Regulates the Expression of Inflammatory Cytokines through the TLR4 Pathway and Improves Skin Wound Healing in Diabetic Rats | Zendy

Zongliang Xiong | Zendy; Mohan Huo | Zendy; Yongzhen Jia | Zendy; Chong Zhou | Zendy; Xianglin Ma | Zendy; Hang Yin | Zendy; Xiaowen Jiang | Zendy; Wenhui Yu | Zendy

Open Access

Dracorhodin Perchlorate Regulates the Expression of Inflammatory Cytokines through the TLR4 Pathway and Improves Skin Wound Healing in Diabetic Rats

Author(s) -

Zongliang Xiong,

Mohan Huo,

Yongzhen Jia,

Chong Zhou,

Xianglin Ma,

Hang Yin,

Xiaowen Jiang,

Wenhui Yu

Publication year - 2022

Publication title -

evidence-based complementary and alternative medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.552

H-Index - 90

eISSN - 1741-4288

pISSN - 1741-427X

DOI - 10.1155/2022/9050686

Subject(s) - wound healing , medicine , tlr4 , inflammation , nitric oxide synthase , proinflammatory cytokine , enos , diabetes mellitus , pharmacology , nitric oxide , immunology , endocrinology

Background. Dragon’s blood is a natural medicine with hemostatic and blood-activating effects and is used to promote wound healing. Dracorhodin perchlorate (DP) is a stable form of dracarhod and is used as a substitute for cochinchinenin. DP promotes the proliferation of rat fibroblasts and promotes wound healing in rats. Methods. DP ointment (0.2 mg/mL) was applied to the skin wounds of nondiabetic and diabetic rats, and the skin of the wound was collected. Wound healing rate, H&E staining, Masson staining, TLR4 pathway, related inflammatory factors, nitric oxide synthase, and so forth were detected. Results. DP treatment alleviated the prolonged inflammatory cell infiltration time and the increase in the TLR4 pathway and inflammatory factors caused by diabetes. DP also promoted wound healing by increasing eNOS protein expression and NO content in the later stage of wound healing. Conclusion. DP promotes wound healing in diabetic rats by regulating the TLR4 pathway and related inflammatory factors. Therefore, adjuvant treatment of DP can be developed for diabetic wound healing.

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