Enhancing Cytotoxicity of Tamoxifen Using Geranium Oil | Zendy

Dai Mizuno | Zendy; Masahiro Kawahara | Zendy; Keiko Konoha–Mizuno | Zendy; Kentaro Yamazaki | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Enhancing Cytotoxicity of Tamoxifen Using Geranium Oil

Author(s) -

Dai Mizuno,

Masahiro Kawahara,

Keiko Konoha–Mizuno,

Kentaro Yamazaki

Publication year - 2022

Publication title -

evidence-based complementary and alternative medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.552

H-Index - 90

eISSN - 1741-4288

pISSN - 1741-427X

DOI - 10.1155/2022/8091339

Subject(s) - geranium , geraniol , pharmacology , agonist , cytotoxicity , partial agonist , chemistry , biology , essential oil , in vitro , receptor , botany , biochemistry , food science , cultivar

Aromatherapy and plant-based essential oils are widely used as complementary and alternative therapies for various symptoms, including anxiety, mild mood disorders, and cancer-related pain. In a previous study, we developed an in vitro assay using immortalized hypothalamic neuronal cells (GT1-7 cells). In this study, we used this assay to investigate the effects of Geranium oil on the cytotoxicity of the oestrogen receptor (ER) antagonist: tamoxifen (TMX). The results showed that Geranium oil augmented TMX-induced cell death in a dose-dependent manner without directly reducing the viability of GT1-7 cells. Cotreatment with Geranium oil and ER agonist β-estradiol (E2) attenuated the inhibition of GT1-7 cell growth. Moreover, Geranium oil and geraniol, a major constituent of Geranium oil, showed weak agonist activity on ERα and ERβ with geraniol augmenting TMX-induced cell death similar to that observed in Geranium oil. Both compounds impair E2 activity. These data indicate that geraniol is an essential constituent of Geranium oil.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research