Development of Biodegradable Delivery Systems Containing Novel 1,2,4-Trioxolane Based on Bacterial Polyhydroxyalkanoates | Zendy

Sergei Y. Lipaikin | Zendy; Ivan A. Yaremenko | Zendy; Alexander O. Terent’ev | Zendy; Tatiana G. Volova | Zendy; Ekaterina I. Shishatskaya | Zendy

Open Access

Development of Biodegradable Delivery Systems Containing Novel 1,2,4-Trioxolane Based on Bacterial Polyhydroxyalkanoates

Author(s) -

Sergei Y. Lipaikin,

Ivan A. Yaremenko,

Alexander O. Terent’ev,

Tatiana G. Volova,

Ekaterina I. Shishatskaya

Publication year - 2022

Publication title -

advances in polymer technology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.523

H-Index - 44

eISSN - 1098-2329

pISSN - 0730-6679

DOI - 10.1155/2022/6353909

Subject(s) - polyhydroxyalkanoates , zeta potential , materials science , particle size , ozonide , morphology (biology) , chemical engineering , drug delivery , surface modification , nanotechnology , nanoparticle , organic chemistry , chemistry , bacteria , genetics , ozone , engineering , biology

In this work, delivery systems in the form of microparticles and films containing 1,2,4-trioxolane (ozonide, OZ) based on polyhydroxyalkanoates (PHAs) were developed. Main systems’ characteristics were investigated: the particle yield, average diameter, zeta potential, surface morphology, loading capacity, and drug release profile of microparticles, as well as surface morphology and release profiles of OZ-containing films. PHA-based OZ-loaded microparticles have been found to have satisfactory size, zeta potential, and ozonide loading-release behavior. It was noted that OZ content influenced the surface morphology of obtained systems.

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