Oxidative Stress and 4-hydroxy-2-nonenal (4-HNE): Implications in the Pathogenesis and Treatment of Aging-related Diseases | Zendy

Yanling Li | Zendy; Tingting Zhao | Zendy; Jiaxin Li | Zendy; Mengyao Xia | Zendy; Yuling Li | Zendy; Xiaoyu Wang | Zendy; Chuanguo Liu | Zendy; Tingting Zheng | Zendy; Renjie Chen | Zendy; Dongfang Kan | Zendy; Yicheng Xie | Zendy; Jingjie Song | Zendy; Feng Yu | Zendy; Tiangui Yu | Zendy; Peng Sun | Zendy

Open Access

Oxidative Stress and 4-hydroxy-2-nonenal (4-HNE): Implications in the Pathogenesis and Treatment of Aging-related Diseases

Author(s) -

Yanling Li,

Tingting Zhao,

Jiaxin Li,

Mengyao Xia,

Yuling Li,

Xiaoyu Wang,

Chuanguo Liu,

Tingting Zheng,

Renjie Chen,

Dongfang Kan,

Yicheng Xie,

Jingjie Song,

Feng Yu,

Tiangui Yu,

Peng Sun

Publication year - 2022

Publication title -

journal of immunology research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.315

H-Index - 83

eISSN - 2314-8861

pISSN - 2314-7156

DOI - 10.1155/2022/2233906

Subject(s) - lipid peroxidation , oxidative stress , 4 hydroxynonenal , malondialdehyde , signal transduction , biochemistry , dna damage , glutathione , pathogenesis , microbiology and biotechnology , biology , chemistry , dna , enzyme , immunology

Oxidative stress plays an important role in the development of aging-related diseases by accelerating the lipid peroxidation of polyunsaturated fatty acids in the cell membrane, resulting in the production of aldehydes, such as malondialdehyde and 4-hydroxy-2-nonenal (4-HNE) and other toxic substances. The compound 4-HNE forms adducts with DNA or proteins, disrupting many cell signaling pathways including the regulation of apoptosis signal transduction pathways. The binding of proteins to 4-HNE (4-HNE-protein) acts as an important marker of lipid peroxidation, and its increasing concentration in brain tissues and fluids because of aging, ultimately gives rise to some hallmark disorders, such as neurodegenerative diseases (Alzheimer’s and Parkinson’s diseases), ophthalmic diseases (dry eye, macular degeneration), hearing loss, and cancer. This review aims to describe the physiological origin of 4-HNE, elucidate its toxicity in aging-related diseases, and discuss the detoxifying effect of aldehyde dehydrogenase and glutathione in 4-HNE-driven aging-related diseases.

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