Concurrent B Cell Acute Lymphoblastic Lymphoma/Leukemia and Monoclonal B Cell Lymphocytosis: A Case Report with Extensive Molecular Analysis | Zendy

Maryam Mehdipour Dalivand | Zendy; Parastou Tizro | Zendy; Julie Partain | Zendy; Anita Aggarwal | Zendy; Jack Lichy | Zendy; Francisco Mot Ara | Zendy; Victor E. Nava | Zendy

Open Access

Concurrent B Cell Acute Lymphoblastic Lymphoma/Leukemia and Monoclonal B Cell Lymphocytosis: A Case Report with Extensive Molecular Analysis

Author(s) -

Maryam Mehdipour Dalivand,

Parastou Tizro,

Julie Partain,

Anita Aggarwal,

Jack Lichy,

Francisco Mot Ara,

Victor E. Nava

Publication year - 2022

Publication title -

case reports in hematology

Language(s) - English

Resource type - Journals

eISSN - 2090-6560

pISSN - 2090-6579

DOI - 10.1155/2022/1132544

Subject(s) - lymphocytosis , medicine , lymphoma , monoclonal , leukemia , immunophenotyping , b cell , pathogenesis , chemotherapy , immunology , pathology , monoclonal antibody , cancer research , antigen , antibody

Although acute lymphoblastic leukemia (ALL) and monoclonal B cell lymphocytosis (MBL) are common neoplasia, a simultaneous presentation is very unusual. Here, we present two different B cell clones, MBL and B-ALL, cocirculating in a 78-year-old African American male. Detailed molecular characterization revealed an unusual MPL (T487I) point mutation and unmutated VH4-39. After nonstandard chemotherapy, the patient remains in morphologic remission. These findings may stimulate further research to clarify the pathogenesis of hematologic neoplasms.

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