Microbiome and Gestational Diabetes: Interactions with Pregnancy Outcome and Long-Term Infant Health | Zendy

Caterieri | Zendy; Erika Serafino | Zendy; Maddalena Morlando | Zendy; Alessandra Familiari | Zendy

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Microbiome and Gestational Diabetes: Interactions with Pregnancy Outcome and Long-Term Infant Health

Author(s) -

Caterieri,

Erika Serafino,

Maddalena Morlando,

Alessandra Familiari

Publication year - 2021

Publication title -

journal of diabetes research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.034

H-Index - 50

eISSN - 2314-6753

pISSN - 2314-6745

DOI - 10.1155/2021/9994734

Subject(s) - gestational diabetes , microbiome , pregnancy , medicine , diabetes mellitus , obstetrics , adverse effect , gestation , gut flora , gut microbiome , physiology , bioinformatics , biology , immunology , endocrinology , genetics

Microbiota composition is progressively being connected to different physiologic effects, such as glucose metabolism, and also to different pathologies, such as gestational diabetes mellitus (GDM). GDM is a public health concern that affects an important percentage of pregnancies and is correlated with many adverse maternal and neonatal outcomes. An increasing number of studies are showing some connections between specific microbial composition of the gut microbiota and development of GDM and adverse outcomes in mothers and neonates. The aim of this review is to analyze the available data on microbial changes that characterize healthy pregnancies and pregnancies complicated by GDM and to understand the correlation of these changes with adverse maternal outcomes; this review will also discuss the consequences of these maternal gut microbiome alterations on neonatal microbiota composition and neonatal long-term outcomes.

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