Metastatic Seminoma with Positive Staining of Cytokeratin and MOC31: A Diagnostic Pitfall | Zendy

Jiaming Fan | Zendy; Ren Yuan | Zendy; David Stefanelli | Zendy; Gang Wang | Zendy

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Metastatic Seminoma with Positive Staining of Cytokeratin and MOC31: A Diagnostic Pitfall

Author(s) -

Jiaming Fan,

Ren Yuan,

David Stefanelli,

Gang Wang

Publication year - 2021

Publication title -

case reports in pathology

Language(s) - English

Resource type - Journals

eISSN - 2090-6781

pISSN - 2090-679X

DOI - 10.1155/2021/9992978

Subject(s) - seminoma , cytokeratin , medicine , pathology , metastasis , immunohistochemistry , germ cell , testicle , lymph , germ cell tumors , dysgerminoma , stage (stratigraphy) , cancer , biology , chemotherapy , paleontology , biochemistry , ovary , gene

Retroperitoneal metastasis of seminoma often occurs in the higher stage through lymph nodes. Generally, seminoma expresses specific germ cell markers while being negative for carcinoma markers. We present a unique case of cytokeratin positive seminoma initially presented as retroperitoneal metastasis. The diagnosis was made based on the histological features and immunohistochemical stains. Testicular ultrasound confirmed the primary tumor in the patient's left testicle. Pathologists should always be aware of germ cell tumors when encountering a metastasis of an unknown primary.

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