Antibacterial and Anti-Inflammatory Potential of Polyherbal Formulation Used in Chronic Wound Healing | Zendy

Ilona Mandrika | Zendy; Somit Kumar | Zendy; Baiba Zandersone | Zendy; Sujith Eranezhath | Zendy; Ramona Petrovska | Zendy; Iveta Līduma | Zendy; Arnolds Jezupovs | Zendy; Valdis Pīrāgs | Zendy; Tatjana Tračevska | Zendy

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Antibacterial and Anti-Inflammatory Potential of Polyherbal Formulation Used in Chronic Wound Healing

Author(s) -

Ilona Mandrika,

Somit Kumar,

Baiba Zandersone,

Sujith Eranezhath,

Ramona Petrovska,

Iveta Līduma,

Arnolds Jezupovs,

Valdis Pīrāgs,

Tatjana Tračevska

Publication year - 2021

Publication title -

evidence-based complementary and alternative medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.552

H-Index - 90

eISSN - 1741-4288

pISSN - 1741-427X

DOI - 10.1155/2021/9991454

Subject(s) - staphylococcus aureus , microbiology and biotechnology , proinflammatory cytokine , staphylococcus epidermidis , antibacterial activity , pseudomonas aeruginosa , pathogenic bacteria , multiple drug resistance , minimum inhibitory concentration , chemistry , bacteria , medicine , pharmacology , antimicrobial , antibiotics , inflammation , biology , immunology , genetics

Objective Polyherbal formulations Jathyadi Thailam and Jatyadi Ghritam ( JT ) are used in Indian traditional medicine for diabetic chronic wounds, fistula, fissure, eczema, and burn management. We aimed to investigate the antibacterial and anti-inflammatory properties of crude hexane and ethanol extracts of JT formulations.Methods Antibacterial activity of JT extracts was tested to estimate minimum inhibitory concentrations (MICs) against nine reference bacterial strains, including one methicillin-resistant Staphylococcus aureus (MRSA) and multidrug-resistant (MDR) Pseudomonas aeruginosa , and clinical strains of methicillin-susceptible S.aureus (MSSA), all involved in diabetic foot infection. The anti-inflammatory activity of plant extracts was evaluated in LPS-treated macrophage cells by measuring the mRNA levels and secretion of inflammatory mediators.Results The antibacterial activity of JT extracts was higher against Gram (+) bacteria, with the MICs varying from 1.95 to 62.5 mg/mL. Gram (−) bacteria were only susceptible to ethanol extracts of JT . Plant extracts were found to be the most active against the reference and clinical strains of MSSA, MRSA, and biofilm-forming S. epidermidis . JT extracts efficiently inhibited in a dose-dependent manner the mRNA expression and protein secretion of proinflammatory cytokines IL-6 and IL-1 β , and chemokines MCP-1 and CXCL10 in LPS-challenged macrophages.Conclusion In the present study, we have shown that extracts of JT formulations possess potent antibacterial and anti-inflammatory properties that could be involved in chronic wound healing activity and has the potential to be used as external add-on therapy in the management of multidrug-resistant bacterial infections at the wound.

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