Synthesis of Silver-Doxycycline Complex Nanoparticles and Their Biological Evaluation on MCF-7 Cell Line of the Breast Cancer | Zendy

Vahid Mohammadkarimi | Zendy; Negar Azarpira | Zendy; Zahra Ghanbarinasab | Zendy; Pezhman Shiri | Zendy; Fatemeh Dehghani | Zendy; Amin Nakhostin-Ansari | Zendy; Fatemeh Tayyebi-Khorrami | Zendy; Amir Atapour | Zendy; Ali Mohammad Amani | Zendy

Open Access

Synthesis of Silver-Doxycycline Complex Nanoparticles and Their Biological Evaluation on MCF-7 Cell Line of the Breast Cancer

Author(s) -

Vahid Mohammadkarimi,

Negar Azarpira,

Zahra Ghanbarinasab,

Pezhman Shiri,

Fatemeh Dehghani,

Amin Nakhostin-Ansari,

Fatemeh Tayyebi-Khorrami,

Amir Atapour,

Ali Mohammad Amani

Publication year - 2021

Publication title -

journal of chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.436

H-Index - 50

eISSN - 2090-9063

pISSN - 2090-9071

DOI - 10.1155/2021/9944214

Subject(s) - mcf 7 , chemistry , silver nanoparticle , breast cancer , doxycycline , cancer , cancer cell lines , cell culture , nanoparticle , nanotechnology , cancer research , human breast , cancer cell , medicine , biochemistry , antibiotics , materials science , biology , genetics

In the current study, we aim to evaluate the effect of the combination of silver and doxycycline (silver-doxycycline complex) on the viability of the MCF-7 cell line of the breast in comparison with each of them. The Ag-doxycycline NPs were synthesized using silver nitrate and doxycycline solutions. The synthesized Ag-doxycycline NPs were characterized with several analyses. Ag-doxycycline NPs with a concentration of 25 μM is significantly more effective in decreasing the viability of MCF-7 cells than Ag with the same concentration ( P < 0.05 ). Doxycycline with a concentration of 6.25 μM also has a more potent effect on the viability of MCF-7 cells than Ag with the same concentration ( P < 0.05 ). Ag-doxycycline NPs with a 25 μM concentration is more effective than the concentration of 3.125 μM ( P < 0.05 ). Ag-doxycycline NPs were found to be more effective than AgNPs alone in inhibiting the growth of the MCF-7 cells. Also, the increasing utility of nanotechnology in multiple aspects of medicine can lead to using this technology in the treatment of different types of cancer in the future.

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