Ferroptosis: Opportunities and Challenges in Myocardial Ischemia‐Reperfusion Injury | Zendy

Weikun Zhao | Zendy; Yao Zhou | Zendy; Tongtong Xu | Zendy; Qi Wu | Zendy

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Ferroptosis: Opportunities and Challenges in Myocardial Ischemia‐Reperfusion Injury

Author(s) -

Weikun Zhao,

Yao Zhou,

Tongtong Xu,

Qi Wu

Publication year - 2021

Publication title -

oxidative medicine and cellular longevity

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.494

H-Index - 93

eISSN - 1942-0900

pISSN - 1942-0994

DOI - 10.1155/2021/9929687

Subject(s) - reperfusion injury , myocardial reperfusion injury , ischemia , myocardial ischemia , cardiology , medicine

Ferroptosis is a newly discovered form of regulated cell death dependent on iron and reactive oxygen species (ROS). It directly or indirectly affects the activity of glutathione peroxidases (GPXs) under the induction of small molecules, causing membrane lipid peroxidation due to redox imbalances and excessive ROS accumulation, damaging the integrity of cell membranes. Ferroptosis is mainly characterized by mitochondrial shrinkage, increased density of bilayer membranes, and the accumulation of lipid peroxidation. Myocardial ischemia-reperfusion injury (MIRI) is an unavoidable risk event for acute myocardial infarction. Ferroptosis is closely associated with MIRI, and this relationship is discussed in detail here. This review systematically summarizes the process of ferroptosis and the latest research progress on the role of ferroptosis in MIRI to provide new ideas for the prevention and treatment of MIRI.

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