Berberine Reshapes the Balance of the Local Renin-Angiotensin System by Modulating Autophagy under Metabolic Stress in Pancreatic Islets | Zendy

Chenghu Huang | Zendy; Lei Pan | Zendy; Caibi Peng | Zendy; Min Li | Zendy; Yifei Guo | Zendy; Xuefeng Li | Zendy

Open Access

Berberine Reshapes the Balance of the Local Renin-Angiotensin System by Modulating Autophagy under Metabolic Stress in Pancreatic Islets

Author(s) -

Chenghu Huang,

Lei Pan,

Caibi Peng,

Min Li,

Yifei Guo,

Xuefeng Li

Publication year - 2021

Publication title -

journal of the renin-angiotensin-aldosterone system

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.457

H-Index - 46

eISSN - 1752-8976

pISSN - 1470-3203

DOI - 10.1155/2021/9928986

Subject(s) - berberine , autophagy , endocrinology , medicine , downregulation and upregulation , islet , chemistry , pancreatic islets , renin–angiotensin system , insulin , microbiology and biotechnology , biology , apoptosis , biochemistry , gene , blood pressure

Results Prolonged exposure to palmitate increased the expression of ACE and AngII type 1 receptor (ATR1) and decreased the ACE2 expression, which was partly offset by berberine. In ob/ob mice, berberine increased in tolerance to glucose, improved abnormal β -cell and α -cell distributions, upregulated ACE2 expression, and decreased autophagosomes and the expression of LC3 and SQSTM1/p62. Autophagosomes and expression of LC3 and SQSTM1/p62 were increased in ACE2KO mice.Conclusions We demonstrated that berberine may improve the pancreatic islet function by regulating local RAS-mediated autophagy under metabolic stress.

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