Open AccessFrequency of Aspirin Resistance in Ischemic Stroke Patients and Healthy Controls from Colombia
Author(s) -
Alejandro Román-Gonzaléz,
Carlos Andrés Naranjo,
Walter D. Cardona Maya,
Dionis Vallejo,
F. Navarro Garcia,
César Augusto Franco,
Leonor Alvarez,
Luis Ignacio Tobón,
Marta Ibeth López,
Carolina Rúa,
Gabriel Bedoya,
Ángela P. Cadavid,
José Domingo Torres
Publication year - 2021
Publication title -
stroke research and treatment
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.939
H-Index - 34
eISSN - 2090-8105
pISSN - 2042-0056
DOI - 10.1155/2021/9924710
Subject(s) - aspirin , medicine , ischemic stroke , stroke (engine) , diabetes mellitus , cardiology , ischemia , endocrinology , mechanical engineering , engineering
Objective To evaluate the aspirin resistance prevalence in patients with previous ischemic cerebrovascular disease undergoing aspirin therapy for secondary prevention.Materials and Methods Three hundred fifty patients presenting ischemic strokes and 100 healthy controls under aspirin treatment were evaluated using the optic platelet aggregation test.Results Aspirin resistance was found in 7.4% of the patients with ischemic stroke and 4% of controls. Aspirin resistance was associated with stroke recurrence in univariate analysis ( p = 0.004). Aspirin resistance was not associated with smoking, diabetes, or hypercholesterolemia.Conclusion Aspirin resistance is present in Colombian patients with ischemic stroke as well as in healthy controls.
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