Tolvaptan Response in a Hyponatremic Newborn with Syndrome of Inappropriate Secretion of Antidiuretic Hormone | Zendy

Cengiz Zeybek | Zendy; Ali Dinç Bozat | Zendy; Erhan Çalışıcı | Zendy; Ahmet Bolat | Zendy; Belma Saygılı Karagöl | Zendy

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Tolvaptan Response in a Hyponatremic Newborn with Syndrome of Inappropriate Secretion of Antidiuretic Hormone

Author(s) -

Cengiz Zeybek,

Ali Dinç Bozat,

Erhan Çalışıcı,

Ahmet Bolat,

Belma Saygılı Karagöl

Publication year - 2021

Publication title -

case reports in pediatrics

Language(s) - English

Resource type - Journals

eISSN - 2090-6803

pISSN - 2090-6811

DOI - 10.1155/2021/9920817

Subject(s) - tolvaptan , medicine , hyponatremia , antidiuretic , syndrome of inappropriate antidiuretic hormone secretion , vasopressin , hormone , intensive care medicine , pediatrics

The use of tolvaptan to treat both euvolemic and hypervolemic hyponatremia has rapidly increased in recent years. However, data on its effects on children, especially newborns and infants, are limited. Here, we present a newborn who developed syndrome of inappropriate secretion of antidiuretic hormone following an intracranial hematoma drainage operation who was unresponsive to conventional treatments. The infant was successfully treated with tolvaptan, a competitive inhibitor of the vasopressin V2 receptor.

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