Specific Blood Cells Derived from Pluripotent Stem Cells: An Emerging Field with Great Potential in Clinical Cell Therapy | Zendy

Qian Luo | Zendy; Honghu Li | Zendy; Wei Shan | Zendy; Wei Cong | Zendy; Yan Long | Zendy; Shuyang Cai | Zendy; Xiangjun Zeng | Zendy; Xue Li | Zendy; Yulin Xu | Zendy; Xiaoxiao Xu | Zendy; Yi Luo | Zendy; Pengxu Qian | Zendy; He Huang | Zendy

Open Access

Specific Blood Cells Derived from Pluripotent Stem Cells: An Emerging Field with Great Potential in Clinical Cell Therapy

Author(s) -

Qian Luo,

Honghu Li,

Wei Shan,

Wei Cong,

Yan Long,

Shuyang Cai,

Xiangjun Zeng,

Xue Li,

Yulin Xu,

Xiaoxiao Xu,

Yi Luo,

Pengxu Qian,

He Huang

Publication year - 2021

Publication title -

stem cells international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.205

H-Index - 64

eISSN - 1687-9678

pISSN - 1687-966X

DOI - 10.1155/2021/9919422

Subject(s) - induced pluripotent stem cell , stem cell , haematopoiesis , biology , microbiology and biotechnology , cell therapy , medicine , immunology , embryonic stem cell , genetics , gene

Widely known for self-renewal and multilineage differentiation, stem cells can be differentiated into all specialized tissues and cells in the body. In the past few years, a number of researchers have focused on deriving hematopoietic stem cells (HSCs) from pluripotent stem cells (PSCs) as alternative sources for clinic. Existing findings demonstrated that it is feasible to obtain HSCs and certain mature blood lineages from PSCs, except for several issues to be addressed. This short review outlines the technologies used for hematopoietic differentiation in recent years. In addition, the therapeutic value of PSCs as a potential source of various blood cells is also discussed as well as its challenges and directions in future clinical applications.

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