Epigenetic Modulation of Microglia Function and Phenotypes in Neurodegenerative Diseases | Zendy

Li Wang | Zendy; Chao-Chao Yu | Zendy; Xinyuan Liu | Zendy; Xiaoni Deng | Zendy; Qing Tian | Zendy; Yanjun Du | Zendy

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Epigenetic Modulation of Microglia Function and Phenotypes in Neurodegenerative Diseases

Author(s) -

Li Wang,

Chao-Chao Yu,

Xinyuan Liu,

Xiaoni Deng,

Qing Tian,

Yanjun Du

Publication year - 2021

Publication title -

neural plasticity

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.288

H-Index - 68

eISSN - 2090-5904

pISSN - 1687-5443

DOI - 10.1155/2021/9912686

Subject(s) - microglia , epigenetics , neuroscience , neuroinflammation , phenotype , neuroprotection , biology , immunology , inflammation , gene , genetics

Microglia-mediated neuroinflammation is one of the most remarkable hallmarks of neurodegenerative diseases (NDDs), including AD, PD, and ALS. Accumulating evidence indicates that microglia play both neuroprotective and detrimental roles in the onset and progression of NDDs. Yet, the specific mechanisms of action surrounding microglia are not clear. Modulation of microglia function and phenotypes appears to be a potential strategy to reverse NDDs. Until recently, research into the epigenetic mechanisms of diseases has been gradually developed, making it possible to elucidate the molecular mechanisms underlying the epigenetic regulation of microglia in NDDs. This review highlights the function and phenotypes of microglia, elucidates the relationship between microglia, epigenetic modifications, and NDDs, as well as the possible mechanisms underlying the epigenetic modulation of microglia in NDDs with a focus on potential intervention strategies.

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