Uterine Sensitization-Associated Gene-1 in the Progression of Kidney Diseases | Zendy

Xiaohu Li | Zendy; Wenlong Yue | Zendy; Guiwen Feng | Zendy; Jinfeng Li | Zendy

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Uterine Sensitization-Associated Gene-1 in the Progression of Kidney Diseases

Author(s) -

Xiaohu Li,

Wenlong Yue,

Guiwen Feng,

Jinfeng Li

Publication year - 2021

Publication title -

journal of immunology research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.315

H-Index - 83

eISSN - 2314-8861

pISSN - 2314-7156

DOI - 10.1155/2021/9752139

Subject(s) - bone morphogenetic protein , wnt signaling pathway , immune system , kidney , immunology , kidney disease , medicine , biology , immunity , endometrium , cancer research , signal transduction , gene , microbiology and biotechnology , endocrinology , biochemistry

Uterine sensitization-associated gene-1 (USAG-1), originally identified as a secretory protein preferentially expressed in the sensitized rat endometrium, has been determined to modulate bone morphogenetic protein (BMP) and Wnt expression to play important roles in kidney disease. USAG-1 affects the progression of acute and chronic kidney damage and the recovery of allograft kidney function by regulating the BMP and Wnt signaling pathways. Moreover, USAG-1 has been found to be involved in the process of T cell immune response, and its ability to inhibit germinal center activity and reduce humoral immunity is of great significance for the treatment of autoimmune nephropathy and antibody-mediated rejection (AMR) after renal transplantation. This article summarizes the many advances made regarding the roles of USAG-1 in the progression of kidney disease and outlines potential treatments.

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