Effects of Enalapril on TLR2/NF-κB Signaling Pathway and Inflammatory Factors in Rabbits with Chronic Heart Failure | Zendy

Yanping Tang | Zendy; Zelin Xu | Zendy; Xinyu Chen | Zendy; Nan Wang | Zendy; Xu Deng | Zendy; Liqi Peng | Zendy; Qingyang Chen | Zendy; Huzhi Cai | Zendy

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Effects of Enalapril on TLR2/NF-κB Signaling Pathway and Inflammatory Factors in Rabbits with Chronic Heart Failure

Author(s) -

Yanping Tang,

Zelin Xu,

Xinyu Chen,

Nan Wang,

Xu Deng,

Liqi Peng,

Qingyang Chen,

Huzhi Cai

Publication year - 2021

Publication title -

evidence-based complementary and alternative medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.552

H-Index - 90

eISSN - 1741-4288

pISSN - 1741-427X

DOI - 10.1155/2021/9594607

Subject(s) - enalapril , heart failure , tlr2 , signal transduction , medicine , nf κb , downregulation and upregulation , inflammation , cardiac function curve , transcription factor , angiotensin converting enzyme , pharmacology , chemistry , biology , microbiology and biotechnology , blood pressure , tlr4 , biochemistry , gene

Chronic heart failure (CHF) refers to the state of persistent heart failure, which is a complex clinical syndrome of various advanced heart diseases. The toll-like receptor 2 (TLR2)/nuclear transcription factor- κ B (NF- κ B) signal transduction pathway is one of the pathological mechanisms of CHF. Adriamycin can significantly induce the upregulation of TLR2 expression. Angiotensin-converting enzyme inhibitors (ACEI) are commonly used drugs for the treatment of CHF. In our study, the CHF model was established by injection of doxorubicin into the rabbit ear vein. The effect of enalapril on the TLR2/NF- κ B signaling pathway in CHF rabbits has been analyzed and determined. Our research results showed that enalapril reduced the inflammatory response by inhibiting the activation of the TLR2/NF- κ B signaling pathway, thereby improving cardiac structure, myocardial remodeling, and cardiac function.

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