Open AccessStimulation of Codonopsis pilosula Polysaccharide on Bifidobacterium of Human Gut Bacteria In Vitro
Author(s) -
Jiankuan Li,
Lina Dong,
Yue Liu,
Jianping Gao
Publication year - 2021
Publication title -
evidence-based complementary and alternative medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.552
H-Index - 90
eISSN - 1741-4288
pISSN - 1741-427X
DOI - 10.1155/2021/9524913
Subject(s) - bifidobacterium , codonopsis , bacteria , fermentation , polysaccharide , 16s ribosomal rna , prebiotic , gut flora , microbiology and biotechnology , biology , bifidobacterium longum , in vitro , food science , chemistry , biochemistry , lactobacillus , medicine , traditional chinese medicine , genetics , alternative medicine , pathology
Objective To evaluate the prebiotic effects of Codonopsis pilosula polysaccharide (CPP) on human gut bacteria in vitro.Methods Codonopsis Radix was extracted with water at 100°C, and the extract was precipitated by 80% ethanol to obtain CPP. Human fresh fecal samples were collected from three healthy adults and used to ferment CPP. The fermented samples were collected to be analyzed by 16S rRNA sequencing.Results The results showed that CPP exhibited significantly the stimulation on the growth of genus Bifidobacterium of human gut bacteria ( Padj < 0.05). Although CPP also exhibited regulative trends on the genera including Acidaminococcus , Bilophila , Dorea , and Eggerthella , no significant differences were observed ( Padj > 0.05), which was likely associated with the limited samples ( n = 3).Conclusion CPP has the potential to stimulate the growth of Bifidobacterium of the human gut bacteria and to be benefit to human health.
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