The Potential Antioxidant Activity and Characterization of Bioactive Compounds of Stahlianthus involucratus | Zendy

Wengkun Li | Zendy; Bingmin Wu | Zendy; Yange Wang | Zendy; Ying Lin | Zendy; Lin An | Zendy; Guifang Zhang | Zendy

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The Potential Antioxidant Activity and Characterization of Bioactive Compounds of Stahlianthus involucratus

Author(s) -

Wengkun Li,

Bingmin Wu,

Yange Wang,

Ying Lin,

Lin An,

Guifang Zhang

Publication year - 2021

Publication title -

biomed research international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.772

H-Index - 126

eISSN - 2314-6141

pISSN - 2314-6133

DOI - 10.1155/2021/9490162

Subject(s) - antioxidant , oxidative stress , chemistry , polyphenol , orbitrap , antioxidant capacity , biochemistry , pharmacology , chromatography , biology , mass spectrometry

Stahlianthus involucratus ( S. involucratus ) has anti-inflammatory, antinociceptive, and antipyretic activities; however, there are no literature reports on its antioxidant capacity. This study presents a comparative assessment of the polyphenols contents, flavonoids contents, and antioxidant activity of the aqueous and methanol extracts of S. involucratus (ASI and MSI). Moreover, the expression of oxidative stress-related genes in H 2 O 2 -induced H9c2 cells pretreated with the MSI was measured by RT-qPCR, and furthermore, MSI were characterized by UHPLC-Q-Orbitrap-MS/MS. The results indicated that the MSI had higher antioxidant contents and antioxidant capacity, and MSI could inhibit H 2 O 2 -induced oxidative stress in H9c2 cells by activating the Nrf2/HO-1 pathway. UHPLC-Q-Orbitrap-MS/MS characterized 15 phenolic compounds from the MSI. In conclusion, S. involucratus has the potential antioxidant capacity.

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