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Prostaglandin E2 (PGE 2 ) is a lipid mediator derived from the fatty acid arachidonic acid. As an essential inflammatory factor, PGE 2  has a critical impact on immune regulation through the prostanoid E (EP) receptor pathway. T cells, including CD4 +  and CD8 +  T cell subsets, play crucial roles in the adaptive immune response. Previous studies have shown that PGE 2  is involved in regulating CD4 +  T cell differentiation and inflammatory cytokine production via the EP receptor pathway, thereby affecting the development of diseases mediated by CD4 +  T cells. In this review, we summarize the signaling pathway of PGE 2  and describe the relationship between PGE 2  and T cell differentiation. Hence, this review may provide important evidence for immune therapies and may even promote the development of biomedicines.

The Signaling Pathway of PGE2 and Its Regulatory Role in T Cell Differentiation