The Signaling Pathway of PGE2 and Its Regulatory Role in T Cell Differentiation | Zendy

Yang An | Zendy; Jiameng Yao | Zendy; Xiaoyin Niu | Zendy

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The Signaling Pathway of PGE2 and Its Regulatory Role in T Cell Differentiation

Author(s) -

Yang An,

Jiameng Yao,

Xiaoyin Niu

Publication year - 2021

Publication title -

mediators of inflammation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.37

H-Index - 97

eISSN - 1466-1861

pISSN - 0962-9351

DOI - 10.1155/2021/9087816

Subject(s) - lipid signaling , microbiology and biotechnology , immune system , biology , prostaglandin e2 receptor , signal transduction , cytokine , cd8 , t cell , arachidonic acid , mediator , receptor , immunology , inflammation , biochemistry , enzyme , agonist

Prostaglandin E2 (PGE 2 ) is a lipid mediator derived from the fatty acid arachidonic acid. As an essential inflammatory factor, PGE 2 has a critical impact on immune regulation through the prostanoid E (EP) receptor pathway. T cells, including CD4 + and CD8 + T cell subsets, play crucial roles in the adaptive immune response. Previous studies have shown that PGE 2 is involved in regulating CD4 + T cell differentiation and inflammatory cytokine production via the EP receptor pathway, thereby affecting the development of diseases mediated by CD4 + T cells. In this review, we summarize the signaling pathway of PGE 2 and describe the relationship between PGE 2 and T cell differentiation. Hence, this review may provide important evidence for immune therapies and may even promote the development of biomedicines.

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