Hepatoprotective Screening of Seriphidium kurramense (Qazilb.) Y.R. Ling | Zendy

Maroof Ali | Zendy; Hidayat Hussain | Zendy; Amjad Hussain | Zendy; Abdur Rauf | Zendy; Wahid Hussain | Zendy; Manzoor Ullah | Zendy; Safdar Abbas | Zendy; Yahya S. AlAwthan | Zendy; Omar Bahattab | Zendy; Muhammad Khan | Zendy; Ahmed Olatunde | Zendy; Zainab M. Almarhoon | Zendy; Yahia N. Mabkhot | Zendy; Mohammed M. Alshehri | Zendy; Sevgi Durna Daştan | Zendy; Mohamed Fawzy Ramadan | Zendy; Javad SharifiRad | Zendy

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Hepatoprotective Screening of Seriphidium kurramense (Qazilb.) Y.R. Ling

Author(s) -

Maroof Ali,

Hidayat Hussain,

Amjad Hussain,

Abdur Rauf,

Wahid Hussain,

Manzoor Ullah,

Safdar Abbas,

Yahya S. AlAwthan,

Omar Bahattab,

Muhammad Khan,

Ahmed Olatunde,

Zainab M. Almarhoon,

Yahia N. Mabkhot,

Mohammed M. Alshehri,

Sevgi Durna Daştan,

Mohamed Fawzy Ramadan,

Javad SharifiRad

Publication year - 2021

Publication title -

biomed research international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.772

H-Index - 126

eISSN - 2314-6141

pISSN - 2314-6133

DOI - 10.1155/2021/9026731

Subject(s) - carbon tetrachloride , glutathione , malondialdehyde , superoxide dismutase , antioxidant , oxidative stress , chemistry , ccl4 , pharmacology , lipid peroxidation , nitric oxide , biochemistry , glutathione peroxidase , traditional medicine , enzyme , biology , medicine , organic chemistry

Investigation on medicinal plants’ therapeutic potential has gained substantial importance in the discovery of novel effective and safe therapeutic agents. The present study is aimed at investigating the hepatoprotective potential of Seriphidium kurramense methanolic extract (SKM) against carbon tetrachloride- (CCl4-) induced hepatotoxicity in rats. S. kurramense is one of the most imperative plants for its various pharmacological activities. Therefore, this study was aimed at evaluating the hepatoprotective potential against CCl4-induced liver toxicity. The serum samples were analyzed for alanine aminotransferase (ALT) and aspartate aminotransferase (AST) together with the oxidative stress mediator levels as nitric oxide (NO), malondialdehyde (MDA), glutathione (GSH), reduced glutathione (GSH), and superoxide dismutase (SOD) as well as peroxidation and H2O2 activity. CCl4 administration resulted in an elevated free radical generation, altered liver marker (AST and ALT) enzymes, reduced antioxidant enzyme, and increased DNA damage. Methanolic extract of S. kurramense decreased CCl4-induced hepatotoxicity by increasing the antioxidant status and reducing H2O2 and nitrate content generation as well as reducing DNA damage. Additionally, SKM reversed the morphological alterations induced by CCl4 in the SKM-treated groups. These results demonstrated that SKM displayed hepatoprotective activity against CCl4-induced hepatic damage in experimental rats.

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